Pep Guardiola has made nine changes from the side that began the 2-1 win at Luton on Sunday.
Only Mateo Kovacic and Jack Grealish remain in the side, while 20-year-old academy forward Micah Hamilton makes his senior debut and Kalvin Phillips is handed a rare start.
Erling Haaland is still out with a foot problem, but would have almost certainly been rested anyway, with City already qualified for the next round of the Champions League.
Confirmed team: Ortega, Lewis, Stones, Akanji, Gomez, Phillips, Kovacic, Nunes, Bobb, Grealish, Hamilton.
Subs: Carson, Grant, Walker, Dias, Ake, Rodrigo, Alvarez, Bernardo, Gvardiol, Foden, Alleyne, Susoho.
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